Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload
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منابع مشابه
Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload
Because the left ventricular (LV) hypertrophy due to volume overload induced by arteriovenous (AV) shunt was associated with an increase in phospholipase C (PLC) isozyme mRNA levels, PLC is considered to be involved in the development of cardiac hypertrophy. Since the renin-angiotensin system (RAS) is activated in cardiac hypertrophy, the role of RAS in the stimulation of PLC isozyme gene expre...
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Volume overload due to arteriovenous (AV) shunt results in cardiac hypertrophy followed by the progression to heart failure. The phosphoinositide phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP(2)) to 1,2-diacylglycerol (DAG) and inositol (1,4,5)-trisphosphate (IP(3)), which are known to influence cardiac function. Therefore, we examined the time course of changes in D...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2006
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2006.tb00412.x